Perirenal fat: a neglected fat depot shaping heterogeneity of obesity along with hepatic fat
Authors' conclusion
Besides hepatic fat, perirenal fat is also a key determinant for metabolic syndrome. Patients with various metabolic abnormalities present distinct patterns of visceral fat distribution, which could be simply profiled by perirenal and hepatic fat quantification.
Study context
- Population
- Individuals with BMI ≥24 kg/m² with fat-selective magnetic resonance images (MRI)
- Participants
- 319 individuals
- Exposure
- Visceral fat depots across obesity phenotypes
- Outcome
- Primary visceral fats contributing to metabolically unhealthy obesity
Methodological detailsMRI-based fat quantification
- MRI-based fat quantification
Main finding
As reported in the abstract
- Perirenal fat (PrFT) strongest correlation with blood pressure among visceral fats (all p < 0.001)
- r = 0.225 ≈0.306
- Hepatic fat highest association with glucose metabolism (all p < 0.01); higher hepatic fat in T2DM vs other groups
- r = 0.188 ≈0.407
- Metabolic syndrome risk, moderate fatty steatosis vs no hepatic steatosis
- 3.06-fold (95% CI 1.35-6.93, p = 0.007)
- Metabolic syndrome risk, severe fatty steatosis vs no hepatic steatosis
- 6.79-fold (95% CI 2.45-18.83, p < 0.001)
- Metabolic syndrome likelihood per 1 cm increment in PrFT
- 2.24-fold (95% CI 1.27-3.97, p = 0.006)
Observational data: associations, not effects.
Original publication
Perirenal fat: a neglected fat depot shaping heterogeneity of obesity along with hepatic fat. Int J Obes (Lond). Published 26 August 2025. doi:10.
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