Alcoholic Use Disorder Outcomes After Roux‐en‐Y Gastric Bypass in Patients Taking GLP‐1 RAs: A Multicenter Analysis
Authors' conclusion
Post RYGB, GLP-1 RAs provide the potential to reduce AUD and all-cause mortality.
Study context
- Population
- Adults (≥ 18 years old) with obesity (BMI ≥ 30 kg/m²) who underwent RYGB between January 1, 2019, and May 31, 2023 (TriNetX); other liver diseases and other bariatric surgeries excludedPropensity score matching (PSM)-matched cohorts
- Participants
- 3,438 vs 3,438
- Exposure
- GLP-1 RA initiation vs non-GLP-1 RA use after RYGB
- GLP-1 RAn = 3,438
- Non-GLP-1 RAn = 3,438reference
- Outcome
- Alcohol use disorders (AUD)
- Follow-up
- ≥1 year
Methodological detailsmulticenter, propensity score matching
- Multicenter
- Propensity score matching
Main finding
As reported in the abstract
Hazard ratio
0.77
95% CI 0.549–0.840
P = 0.041
By group
Between GLP-1 RA and Non-GLP-1 RA
HR 0.77 (95% CI 0.549–0.840); P = 0.041
Observational data: associations, not effects.
Further findings
| Outcome | GLP-1 RA | Non-GLP-1 RA | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| All-cause mortalityAfter PSM | 1.2% | 3.9% | 0.497 (0.346–0.715) | P = 0.039 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Alcoholic Use Disorder Outcomes After Roux‐en‐Y Gastric Bypass in Patients Taking GLP‐1 RAs: A Multicenter Analysis. Obesity (Silver Spring). Published 26 August 2025. doi:10.
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