Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity
Authors' conclusion
In this population, VAT and ASAT appear to be independent predictors of cardiometabolic risk and insulin resistance, respectively.
Study context
- Population
- Children with overweight/obesity (54.4% girls, 10.6 ± 1.1 years); fat depots (VAT, ASAT, IMAAT, lumbar spine bone marrow, hepatic and pancreatic fat) measured by MRI
- Participants
- 114 children
- Outcome
- Associations of specific fat depots with age- and sex-reference based cardiometabolic risk score and insulin resistance
Main finding
As reported in the abstract
- Univariate: VAT, ASAT, IMAAT and hepatic fat associated with cardiometabolic risk score
- β = 0.308-0.526, p ≤ 0.001
- Univariate: VAT, ASAT, IMAAT and hepatic fat associated with insulin resistance
- β = 0.227-0.412, p < 0.05
- Adjusted for other fat variables: VAT the only depot independently associated with cardiometabolic risk score
- β = 0.450, p < 0.001
- Adjusted for other fat variables: ASAT the only depot independently associated with insulin resistance
- β = 0.393, p < 0.001
- Hepatic fat not independently associated with cardiometabolic risk score or insulin resistance
- p ≥ 0.256
Observational data: associations, not effects.
Original publication
Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity. Pediatr Obes. Published 2 March 2026. doi:10.
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