Lipids & metabolic liver disease
Periodontitis adversely affects lipoprotein subfractions – results from the cohort study SHIP-TREND: Periodontitis adversely affects lipoprotein subfractions
Authors' conclusion
This study provides evidence for causal effects of periodontitis on conventional serum lipids and plasma lipoprotein subfractions. As the underlying biological mechanisms are not fully understood, further research is needed.
Study context
- Population
- Participants of the population-based Study of Health in Pomerania (SHIP-TREND) with 7-year follow-up data
- Participants
- 2,058 participants
- Exposure
- Periodontitis and number of missing teeth vs serum lipoproteins and plasma subfractions
- Outcome
- Serum lipoproteins and plasma lipoprotein subfractions (1H-NMR spectroscopy)
- Follow-up
- 7-year follow-up
Methodological detailspropensity score weighting, 7-year follow-up
- Propensity score weighting
- 7-year follow-up
Main finding
As reported in the abstract
- Periodontal variables consistently associated with elevated follow-up serum TG, total cholesterol and LDL-C
- Periodontal variables associated with elevated TG- and cholesterol-enriched apolipoprotein B-containing lipoprotein particles, particularly small dense LDL, VLDL and IDL
- Altered HDL particle composition, suggesting potential functional changes
Observational data: associations, not effects.
Original publication
Periodontitis adversely affects lipoprotein subfractions – results from the cohort study SHIP-TREND: Periodontitis adversely affects lipoprotein subfractions. Diabetes Metab. Published 11 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →