Lipids & metabolic liver disease
Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans
Authors' conclusion
Taken together, we found no metabolic signature of selective hepatic IR in fasting humans. DNL may contribute to hypertriglyceridemia in individuals with HI but not those with HF. Glycogenolysis and systemic glucose clearance may have a larger contribution to fasting hyperglycemia than gluconeogenesis, especially in those with HF, and these pathways should be considered for therapeutic targeting.
Study context
- Population
- Medication-free men and women across a range of adiposity
- Participants
- 177 men
- Exposure
- Hyperinsulinemic vs normoinsulinemic; high vs low liver fat
- Outcome
- Fasting markers of selective hepatic insulin resistance (IR) (frGNG, hepatic DNL)
- Follow-up
- After overnight fast
Methodological detailsstable isotope tracer methodology, overnight fast
- Stable isotope tracer methodology
- Overnight fast
Main finding
As reported in the abstract
- Hyperinsulinemic (HI) and HF had higher fasting plasma glucose and TG vs normoinsulinemic (NI) and LF respectively
- No difference in frGNG (HI vs NI; HF vs LF)
- HF tended to have lower frGNG than LF
- HI had higher de novo lipogenesis (DNL) than NI
- No difference in DNL between liver fat groups
Observational data: associations, not effects.
Original publication
Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans. Eur J Endocrinol. Published 1 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →