Percutaneous Ablation of Parathyroid Adenomas: A Systematic Review and Meta-Analysis
Authors' conclusion
Our findings indicate that percutaneous ablation of parathyroid adenomas is safe and effective within the first year of the treatment. Additionally, they suggest that RF, MWA, and ethanol ablation techniques can each be employed depending on patients' needs without particular limitations.
Study context
- Population
- Patients with PHPT due to parathyroid adenomas treated by percutaneous ablation
- Participants
- 815 patients20 studies
- Comparison
- Radiofrequency (RF) vs microwave ablation (MWA) vs ethanol ablation of parathyroid adenomas
- Outcome
- Changes in serum calcium, PTH and phosphorus levels, and normocalcemia rates
- Follow-up
- 6 to 12 months after ablation
Methodological detailsrandom-effects model, PRISMA
- Random-effects model
- PRISMA
Pooled result
As reported in the abstract
Normocalcemia rate · 6 to 12 months
Posttreatment normocalcemia rate
pooled 85.6%
95% CI 80.48–90.72
Serum PTH decrease, MD
101.49 pg/mL
95% CI 73.50–129.48
Serum calcium decrease, MD
0.39 mmol/L
95% CI 0.34-.45
Safety
- Permanent hoarseness incidence
- 0.28% (95% CI 0.00-1.05)
- Major complications incidence
- 0.31% (95% CI 0.00-1.09)
- Safety outcomes of RF, MWA and ethanol ablation were comparable
Original publication
Percutaneous Ablation of Parathyroid Adenomas: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. Published 6 May 2025. doi:10.
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