Ultrasound‐Guided Radiofrequency Ablation for the Treatment of Primary Hyperparathyroidism in Elderly Patients
Authors' conclusion
Ultrasound-guided RFA appears to be an effective and safe minimally invasive treatment option for selected elderly patients with PHPT, achieving acceptable cure rates with a favorable safety profile.
Study context
- Population
- Patients aged ≥60 years with PHPT who underwent US-guided radiofrequency ablation (RFA) at a single center, May 2021–May 2025; mean age 70.4 (±8.69) yearsanalysed
- Participants
- 36 patients
- Outcome
- Cure: normalization of both serum calcium and intact parathyroid hormone (iPTH) levels during follow-up
- Follow-up
- ≥6 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Cure (normalization of both serum calcium and iPTH during follow-up)
Cure after a single RFA session
28 of 36
Overall cure rate including repeat procedures
83.3%
30/36
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Cure after a single RFA session | RFA 28 events |
- Cure after a single RFA session: 28 of 36 patients
Baseline characteristics, cured vs non-cured
- Baseline characteristics did not differ significantly between cured and non-cured patients
Safety
Procedure-related adverse events
- Permanent hoarseness
- 1 patient
- Major life-threatening complications
- 0
- Key adverse events were postoperative mild pain and hoarseness; hoarseness transient in most cases
- Patients with hoarseness were older and had lower baseline magnesium than those without
Original publication
Ultrasound‐Guided Radiofrequency Ablation for the Treatment of Primary Hyperparathyroidism in Elderly Patients. Clin Endocrinol (Oxf). Published 2 April 2026. doi:10.
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