Association Between Radius Axial Low-Frequency Ultrasound Velocity and Bone Fragility in Primary Hyperparathyroidism
Authors' conclusion
VLF could be used for screening purposes prior to DXA to evaluate PHPT fracture risk, only in conditions in which DXA measurement cannot be performed.
Study context
- Population
- Postmenopausal women with PHPT; mean age 68 ± 10 years
- Participants
- 117 women
- Exposure
- Radius VLF axial transmission ultrasound vs DXA
- Outcome
- Radius VLF ultrasound as screening tool for skeletal fragility
Main finding
As reported in the abstract
Agreement between radius DXA and VLF: K
0.43
P < .001
Lower radius ultrasound T-score (adjusted for years since menopause and BMI) associated with DXA osteoporosis at lumbar and/or femoral neck sites: OR
1.852
CI 1.08, 3.18
Observational data: associations, not effects.
Further findings
All fractures
- Femoral neck T-score: OR
- 1.89 (95% CI 1.24, 2.89)
- Total hip T-score: OR
- 1.65 (95% CI 1.09, 2.50)
- Years since menopause: OR
- 1.25 (95% CI 1.02, 1.54)
Morphometric vertebral fractures
- Years since menopause: OR
- 1.28 (95% CI 1.02, 1.61)
- Femoral neck T-score: OR
- 1.96 (95% CI 1.227, 3.135)
- Total hip T-score: OR
- 1.64 (95% CI 1.04, 2.60)
- Trabecular bone score (TBS): OR
- 0.779 (95% CI 0.60-0.99)
- Ultradistal radius T-score: OR
- 1.50 (95% CI 1.05, 2.156)
- Radius ultrasound T-score: OR
- 1.67 (95% CI 1.09, 2.56)
Original publication
Association Between Radius Axial Low-Frequency Ultrasound Velocity and Bone Fragility in Primary Hyperparathyroidism. J Clin Endocrinol Metab. Published 5 October 2024. doi:10.
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