The quantification of bone mineral density using photon counting computed tomography and its implications for detecting bone remodeling
Main finding · Tt.vBMD accuracy, PCCT vs HR-pQCTResult — go to the resultbias 7.46 mgHA/cm³Authors' conclusion
Based on the cadaver data, we conclude that PCCT can be used to quantify vBMD and bone turnover.
Study context
- Population
- Eight cadaveric forearms (PCCT twice, HR-pQCT once) and dominant forearm of two volunteers (PCCT twice); carpals delineated8 cadaveric forearms · 2 volunteers
- Comparison
- PCCT vs HR-pQCT
- Outcome
- Tt.vBMD accuracy, PCCT vs HR-pQCT
Methodological detailsex vivo cadaveric forearms, in vivo volunteers, phantom calibration
- Ex vivo cadaveric forearms
- In vivo volunteers
- Phantom calibration
Main finding
As reported in the abstract
bias
7.46 mgHA/cm³
- Pearson correlation of paired Tt.Volumetric BMD (vBMD)
- 0.986
Further findings
Voxel-level repeatability of repeated PCCT scans (ex vivo)
mgHA/cm³
- Bias
- 17.66
- SE
- 96.23
Least detectable remodeling
- Least detectable remodeling threshold
- 250 mgHA/cm³
- Voxels incorrectly classified as newly added or resorbed bone (ex vivo)
- 0.37%
- Voxels incorrectly classified (in vivo)
- 0.97%
Original publication
The quantification of bone mineral density using photon counting computed tomography and its implications for detecting bone remodeling. J Bone Miner Res. Published 4 October 2024. doi:10.
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