mRNA expression of vitamin D receptor, calcium-sensing receptor, cyclin D1, and parathyroid hormone (PTH) in symptomatic and asymptomatic primary hyperparathyroidism
Authors' conclusion
Symptomatic PHPT patients had significantly greater CD1 mRNA expression and lower CaSR expression than asymptomatic patients, underscoring the importance of the molecular mechanisms underlying the phenotypic heterogeneity of PHPT.
Study context
- Population
- Asian Indian patients with sporadic primary hyperparathyroidism (PHPT) who underwent parathyroidectomy, tertiary care hospital in North India; mean (SD) age 49.7 (12.8) years
- Participants
- 42 PHPT patients
- Exposure
- Symptomatic vs asymptomatic PHPT vs controls
- Asymptomaticn = 20
- Outcome
- VDR, CaSR, CD1 and PTH mRNA levels (quantitative real-time polymerase chain reaction (qRT-PCR)) in symptomatic and asymptomatic PHPT vs controls
Methodological detailssingle-centre, tertiary care hospital
- Single-centre
- Tertiary care hospital
Main finding
As reported in the abstract
VDR, CaSR, CD1 and PTH mRNA expression
- Calcium-sensing receptor (CaSR) and vitamin D receptor (VDR) mRNAs significantly lower in both symptomatic and asymptomatic patients vs controls
- CD1 and PTH mRNAs significantly increased in symptomatic patients, but not in asymptomatic patients, vs controls
- Symptomatic vs asymptomatic: significantly greater CD1 mRNA expression and reduced CaSR expression
Observational data: associations, not effects.
Further findings
Median, pg/mL
| Outcome | Symptomatic | Asymptomatic |
|---|---|---|
| Serum PTH | 878 | 653 |
Serum PTH
- Median PTH significantly greater in symptomatic than asymptomatic
Original publication
mRNA expression of vitamin D receptor, calcium-sensing receptor, cyclin D1, and PTH in symptomatic and asymptomatic primary hyperparathyroidism. Eur J Endocrinol. Published 1 October 2024. doi:10.
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