Long-term Recurrence Rates After Surgery in Primary Hyperparathyroidism
Authors' conclusion
Approximately 1.56% of sporadic PHPT patients eventually develop recurrence following parathyroidectomy. The initial diagnosis and procedure type does not influence recurrence rates. Consistent long-term follow-up is warranted to help identify recurrent disease.
Study context
- Population
- Patients with sporadic primary hyperparathyroidism (PHPT) after successful parathyroidectomy
- Participants
- 30,658 patients34 studies
- Outcome
- Long-term recurrence rate of sporadic PHPT after successful parathyroidectomy
Methodological detailsmeta-analysis of proportions, ≥5 years of follow-up, Databases searched from inception to January 18, 2023, Quality appraised with National Institutes of Health study quality assessment tools
- Meta-analysis of proportions
- ≥5 years of follow-up
- Databases searched from inception to January 18, 2023
- Quality appraised with National Institutes of Health study quality assessment tools
Pooled result
As reported in the abstract
Pooled overall recurrence rate
Pooled overall recurrence rate
1.56%
95% CI 0.96–2.28%; I2 = 91%
Patients with recurrence after resection
350
1.1%
Further pooled results
5-year recurrence rate
- Pooled 5-year recurrence rate (0.04-0.53%, 19 studies; I2 = 66%)
- 0.23%
10-year recurrence rate
- Pooled 10-year recurrence rate (0.45-1.80%, 14 studies; I2 = 89%)
- 1.03%
Sensitivity analyses
- No statistically significant difference when adjusting for study size, diagnosis, or surgical approach
Original publication
Long-term Recurrence Rates After Surgery in Primary Hyperparathyroidism. J Clin Endocrinol Metab. Published 3 June 2023. doi:10.
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