The Effect of Preoperative Biochemical Parameters on the Development of Hungry Bone Syndrome After Surgery for Primary Hyperparathyroidism
Authors' conclusion
The patients with HBS had higher levels of calcium and parathyroid hormone preoperatively, along with larger resected parathyroid glands. Nevertheless, preoperative parameters were unable to predict HBS. Therefore, biochemical monitoring after surgery seems necessary to detect HBS and protect patients from severe hypocalcemia.
Study context
- Population
- Patients with PHPT who underwent successful parathyroidectomy, January 2010 to January 2020; 73.6% women, median age 54 years
- Participants
- 144 patients
- Exposure
- Patients with hungry bone syndrome (HBS) vs without HBS after parathyroidectomy
- HBSn = 25
- Outcome
- Incidence of HBS and effect of preoperative biochemical parameters on HBS
Main finding
As reported in the abstract
Incidence of HBS
HBS
17.36%
25
- HBS by sex: 5 men and 20 women
- P = 0.425
Observational data: associations, not effects.
Further findings
Postoperative outcomes
- Longer hospital stays and lower serum phosphorus with HBS
Original publication
The Effect of Preoperative Biochemical Parameters on the Development of Hungry Bone Syndrome After Surgery for Primary Hyperparathyroidism. Clin Endocrinol (Oxf). Published 12 May 2025. doi:10.
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