Association between bisphosphonate use and stroke risk: a meta-analysis
Pooled result · StrokeResult — go to the resultPooled relative risk 0.87 95% CI 0.76–0.99Authors' conclusion
Our results suggest that bisphosphonate use is associated with a lower risk of stroke. However, the current evidence does not lead to a definite conclusion due to the borderline statistical significance and high between-study heterogeneity. Future studies, especially RCTs, are necessary to assess causality.
Study context
- Population
- Studies evaluating effects of bisphosphonate on stroke risk; PubMed, Embase, Scopus, Cochrane libraries to January 3, 2022 (PubMed updated to August 22, 2022)
- Participants
- 741,274 participants21 studies
- Comparison
- Bisphosphonate use vs controls
- Outcome
- Stroke risk (pooled RR)
Methodological detailsrandom-effects models, 7 RCTs and 14 observational studies, Two or more reviewers independently screened articles, extracted data and assessed study quality
- Random-effects models
- 7 RCTs and 14 observational studies
- Two or more reviewers independently screened articles, extracted data and assessed study quality
Pooled result
Stroke
Pooled relative risk
0.87
95% CI 0.76–0.99
P = 0.048
Bisphosphonatesvs Controls
pooled RR 0.87 (95% CI 0.76–0.99); P = 0.048
As reported in the abstract
Further pooled results
| Outcome | Pooled RR (95% CI) | P value | |
|---|---|---|---|
| Stroke, RCT subgroupI2 = 13.4% · no significant association | 0.93 (0.76–1.13) | P = 0.462 | |
| 0.512Pooled relative risk (log scale) |
Original publication
Association between bisphosphonate use and stroke risk: a meta-analysis. Osteoporos Int. Published 30 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →