Association of Preterm Birth and Low Birthweight with Bone Fractures during Childhood
Authors' conclusion
Children born very preterm or with extremely low birthweight have in general a lower fracture incidence during childhood compared to children born full term and with normal birthweight.
Study context
- Population
- All newborns alive 28 days after birth, Finland 1998–2017 (Medical Birth Register, Care Register for Health Care); fracture visits in specialized healthcare units95,869 fractures
- Participants
- 997,468 participants
- Exposure
- Preterm and low-birthweight newborns vs full-term and normal-birthweight newborns
- Outcome
- Fracture incidence per 100,000 person-years during childhood
- Follow-up
- 0-20 years; mean 10.0 years
Main finding
As reported in the abstract
Fracture incidence
Each group vs termIncidence rate ratio (CI)
Very preterm23% lower fracture incidence with very preterm
0.77(0.70–0.85)
Pretermsimilar fracture rate
0.98(0.95–1.01)
Observational data: associations, not effects.
Further findings
| Outcome | Birthweight <1000 g | Birthweight ≥2500 g |
|---|---|---|
| Fracture incidence by birthweight | 773 per 100,000 person-years | 966 per 100,000 person-years |
Overall fracture incidence · mean follow-up 10.0 years
- Overall incidence of fractures
- 963 per 100,000 person-years
Fracture incidence by birthweight
- Linear increase in fracture rates with birthweight
Original publication
Association of Preterm Birth and Low Birthweight with Bone Fractures during Childhood. J Bone Miner Res. Published 30 May 2023. doi:10.
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