Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents
Authors' conclusion
Low serum 25(OH)D concentrations are associated with unfavorable levels of cardiometabolic markers in children and adolescents. Interventions to improve vitamin D levels in children with a poor status early in life may help to reduce cardiometabolic risk.
Study context
- Population
- Children and adolescents from the pan-European IDEFICS/I.Family cohort with ≥1 serum 25(OH)D measurement at cohort entry or follow-up
- Participants
- 2,171 children
- Exposure
- Serum 25(OH)D as independent variable vs z-scores of cardiometabolic risk markers
- Outcome
- Association of serum 25(OH)D with z-scores of cardiometabolic risk markers (waist circumference, SBP, DBP, HDL, LDL, non-HDL, TG, ApoA1, ApoB, FPG, HOMA-IR, metabolic syndrome score)
Methodological detailslongitudinal, pan-European IDEFICS/I.Family cohort, linear mixed-effect models
- Longitudinal
- pan-European IDEFICS/I.Family cohort
- Linear mixed-effect models
Main finding
As reported in the abstract
Cardiometabolic risk marker z-scores
HOMA-IR z-score change per 5 ng/mL increase in 25(OH)D
decreased by 0.07 units
Observational data: associations, not effects.
Further findings
- 25(OH)D consistently associated with HOMA-IR irrespective of sex or body mass index (BMI) category
Original publication
Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents. J Clin Endocrinol Metab. Published 1 June 2023. doi:10.
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