Effect of Vitamin D3, Omega-3 Fatty Acids, and Exercise on Serum Sclerostin Levels and Bone Turnover Markers
Authors' conclusion
In this 3-year prevention trial among largely vitamin D replete adults age 70 and older, SHEP alone or in combination with omega-3s reduced serum sclerostin levels, while vitamin D3 and omega-3s alone did not affect serum sclerostin levels.
Study context
- Population
- Healthy physically active older adults in 5 European countries; mean age 74.8 ± 4.4 years, 58.9% women, 41.4% 25(OH)D < 20 ng/mL
- Participants
- 1,848 adults
- Comparison
- Vitamin D3 2000 IU/day, omega-3s 1 g/day and strength exercise program (SHEP), alone or combined, vs control
- Primary endpoint
- Changes in yearly serum sclerostin, P1NP and β-CTx levels, adjusted for age, sex, prior falls, study site, baseline BMI and baseline level
- Follow-up
- Over 3 years
Methodological detailsdouble-blind, predefined secondary outcomes, 5 European countries
- Double-blind
- Predefined secondary outcomes
- 5 European countries
Primary result
As reported in the abstract
Serum sclerostin change
Difference, pmol/L (CI)P value
SHEPvs Control exercisegreater decrease with SHEP
−1.56(−2.54 to −0.58)
P = 0.002Omega-3s plus SHEPvs No omega-3s/control exercisegreater decrease with omega-3s plus SHEP
−1.93(−3.31 to −0.54)
P = 0.007Secondary outcomes
P1NP and β-CTx · over 3 years
- No significant effects for any individual treatment or treatment combination
Original publication
Effect of Vitamin D3, Omega-3 Fatty Acids, and Exercise on Serum Sclerostin Levels and Bone Turnover Markers. J Clin Endocrinol Metab. Published 9 December 2024. doi:10.
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