Effectiveness of Bisphosphonates in Young Adults With Fragility Fractures: Representative Population-based Cohort Study
Main finding · Major osteoporotic fracturesResult — go to the resultHazard ratio 0.618 95% CI 0.396–0.963Authors' conclusion
Bisphosphonate therapy significantly reduces fracture risk in premenopausal women with previous osteoporotic fractures, especially at higher cumulative doses. These findings support considering bisphosphonates as a treatment option in premenopausal women at high risk of fractures.
Study context
- Population
- Premenopausal women with osteoporotic fractures, National Health Insurance Service-National Sample Cohort, South Korea, 2003–2014matched from 2087
- Participants
- 132 vs 396
- Exposure
- Bisphosphonate users vs nonusers
- Bisphosphonate usersn = 132
- Nonusersn = 396reference
- Outcome
- Incidence of osteoporotic fractures
Methodological detailspropensity score-matched (age and BMI, 1:3), nationwide
- Propensity score-matched (age and BMI, 1:3)
- Nationwide
Main finding
Major osteoporotic fractures
Hazard ratio
0.618
95% CI 0.396–0.963
Bisphosphonate usersvs Nonusers
HR 0.618 (95% CI 0.396–0.963)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Major osteoporotic fractures, ibandronate usersIbandronate usersvs Nonusers | 0.376 (0.164–0.861) | |
| Nonvertebral fractures, ibandronate usersIbandronate usersvs Nonusers | 0.214 (0.052–0.877) | |
| Major osteoporotic fractures, bisphosphonate use ≥180 daysBisphosphonate use ≥180 daysvs Nonusers | 0.528 (0.300–0.929) | |
| Nonvertebral fractures, bisphosphonate use ≥180 daysBisphosphonate use ≥180 daysvs Nonusers | 0.409 (0.187–0.895) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Effectiveness of Bisphosphonates in Young Adults With Fragility Fractures: Representative Population-based Cohort Study. J Clin Endocrinol Metab. Published 6 December 2024. doi:10.
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