Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial
Authors' conclusion
Among generally healthy older adults, vitamin D3 and omega-3s supplementation did not reduce the incidence rate of VFs. SHEP reduced the incidence rate of total VFs in women and of VF progressions overall.
Study context
- Population
- European older adults (≥70 years) free from major health events in the 5 years prior to enrollment; mean age 74.9 years; 77% low bone mass or osteoporosis; 43.8% 25(OH)D <20 ng/mL
- Participants
- 1,488 adults
- Comparison
- Vitamin D3, omega-3s or simple home exercise program (SHEP), alone or in combination, vs control
- Primary endpoint
- IR of total VFs (any new and progressed VFs), from lateral thoracolumbar DXA scans
- Follow-up
- 3-year follow-up
Methodological detailsmulti-center, 2 × 2 × 2 factorial
- Multi-center
- 2 × 2 × 2 factorial
Primary result
As reported in the abstract
IR of total VFs · 3 years
Incident vertebral fractures (VFs) (all participants)
93
58 new, 35 progressions
Further findings
| Outcome | IR ratio (95% CI) |
|---|---|
| IR of total VFs, women · 3 yearsSHEP vs Control exercise program | 0.52 (0.28–0.98) |
| IR of VF progressions (sensitivity analysis) · 3 yearsSHEP vs Control exercise program · sensitivity analysis | 0.34 (0.16–0.75) |
Original publication
Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial. J Bone Miner Res. Published 10 June 2025. doi:10.
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