Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial
Primary result · TH aBMDResult — go to the resultDifference in adjusted means 0.0035 g/cm 95% CI 0.0011–0.0059Authors' conclusion
Our study suggests a small benefit of 2000 IU vitamin D daily on TH aBMD overall and LS aBMD among men; however, effect sizes were very modest and the clinical impact of these findings is unclear.
Study context
- Population
- Generally healthy older adults age ≥ 70 years; mean age 75 years, 80.4% physically active, 44% 25(OH)D <20 ng/mLwith DXA scans
- Participants
- 1,493 participants
- Comparison
- Vitamin D3, omega-3s and SHEP, alone or in combination, vs no such treatment
- Primary endpoint
- Areal BMD (LS, FN, total hip (TH)) by DXA (a secondary outcome of DO-HEALTH)
- Follow-up
- 3 years
Methodological detailsmulticenter, double-blind, 2 × 2 × 2 factorial, 3-year
- Multicenter
- Double-blind
- 2 × 2 × 2 factorial
- 3-year
Primary result
TH aBMD · across 3 years
Difference in adjusted means
0.0035 g/cm
95% CI 0.0011–0.0059
Vitamin Dvs No vitamin D
difference in adjusted means 0.0035 g/cm (95% CI 0.0011–0.0059)
As reported in the abstract
Secondary outcomes
| Outcome | ∆AM (g/cm) (95% CI) | P value |
|---|---|---|
| LS aBMD, male subgroupVitamin D vs No vitamin D | 0.0070 (0.0007–0.0132) | interaction P = .003 |
Original publication
Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial. J Bone Miner Res. Published 13 April 2024. doi:10.
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