Postoperative outcome and clinical management of tumor-induced osteomalacia: a single-center retrospective cohort study on 117 patients
Authors' conclusion
TIO patients were able to benefit from the management including early recognition and diagnosis of the disease, identification and complete removal of the causative tumors, followed by regular postoperative surveillance. Of particular concern were patients with bone-derived tumors, who had high non-remission and recurrence rates.
Study context
- Population
- Patients with tumour-induced osteomalacia admitted and surgically treated at one hospital, 2012–2023
- Participants
- 117 patients
- Outcome
- Postoperative outcomes
Methodological detailssingle-centre, All patients managed with a stepwise pathway: diagnosis, tumour identification, operation, postoperative surveillance
- Single-centre
- All patients managed with a stepwise pathway: diagnosis, tumour identification, operation, postoperative surveillance
Main finding
As reported in the abstract
Serum P normal within 7 days after surgery, among cured patients
82.7%
Remained uncured during follow-up
19 patients
Local recurrence
5 patients
Distant metastases
2 patients
Observational data: associations, not effects.
Further findings
Tumour characteristics
- Main sites lower extremities and pelvis
- 63.2%
- Caused by phosphaturic mesenchymal tumours
- 117 cases
- Median tumour volume
- 1.45cm3 (IQR 0.70-4.17 cm³)
- Ki67 labeling index < 10%
- 91.7%
- Tumours equally located in bone and soft tissues
Original publication
Postoperative outcome and clinical management of tumor-induced osteomalacia: a single-center retrospective cohort study on 117 patients. Osteoporos Int. Published 10 June 2025. doi:10.
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