Shift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia
Authors' conclusion
Although aBMD and microstructure in the axial bone were improved, vBMD and microstructure in the peripheral bone were further impaired shortly after surgery. Correlation of improvement of aBMD in the total hip and femoral neck with deterioration of vBMD and microstructure at the distal radius indicated a shift in calcium from the peripheral bone to the axial bone in the short term after tumor resection in TIO patients.
Study context
- Population
- Patients with tumor-induced osteomalacia (TIO) who recovered serum phosphate levels postoperatively
- Participants
- 22 patients
- Exposure
- Bone mineral density (BMD) and microstructure before vs 3 months after tumour resection
- Outcome
- Changes in BMD and microstructure in peripheral (high-resolution peripheral quantitative computed tomography (HR-pQCT)) and axial (DXA) bone
- Follow-up
- 3 months after surgery
Methodological detailsbefore-after comparison
- Before-after comparison
Main finding
As reported in the abstract
- Areal BMD (aBMD) increase, femoral neck
- 21.6%
- aBMD increase, total hip
- 18.9%
- aBMD increase, lumbar spine
- 29.5%
- TBS increase
- 14.1%
- P for all axial increases
- P < .001
Observational data: associations, not effects.
Further findings
Correlation of aBMD changes with peripheral bone changes
- Changes in femoral neck and total hip aBMD inversely associated with changes in trabecular volumetric BMD (vBMD) and bone volume ratio, and positively correlated with change in trabecular separation at distal radius
Original publication
Shift in Calcium From Peripheral Bone to Axial Bone After Tumor Resection in Patients With Tumor-Induced Osteomalacia. J Clin Endocrinol Metab. Published 15 May 2023. doi:10.
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