Approaching virtual osteoid volume estimation and in-depth tissue characterization in patients with tumor-induced osteomalacia
Authors' conclusion
By combining laboratory diagnostics, namely, ALP and Tt.BMDRadius measured by HR-pQCT, we achieved the calculation of the virtual osteoid volume to bone volume ratio (OV/BVmodel) with a significant correlation to histology as well as reliable identification of TIO patients compared to OPO and control.
Study context
- Population
- Patients with tumor-induced osteomalacia, osteoporosis patients and healthy controls; iliac crest biopsies (qBEI, Raman spectroscopy, micro-CT, histology), DXA, high-resolution peripheral quantitative computed tomography (HR-pQCT) and biochemical analyses
- Participants
- 9 / 10 / 10
- Exposure
- Tumor-induced osteomalacia (TIO) vs osteoporosis vs healthy controls
- TIOn = 9
- OPOn = 10
- Healthy controlsn = 10reference
- Outcome
- Histological osteoid volume (OV)
Main finding
As reported in the abstract
P < 0.0005
Observational data: associations, not effects.
Further findings
| Outcome | TIO | Healthy controls | P value |
|---|---|---|---|
| Modeled OV/BVmodel (linear regression of HR-pQCT and laboratory data)TIO vs Healthy controls · significantly higher with TIO | 24.46% ± 14.22% | 5.952% ± 3.44% | P ≤ 0.001 |
Phosphate levels in biopsies (spectroscopy)
- Lower phosphate levels in TIO biopsies
OV/BVmodel from ALP and Tt.BMDRadius (HR-pQCT)
- Significant correlation with histology and reliable identification of TIO vs OPO and controls
Original publication
Approaching virtual osteoid volume estimation and in-depth tissue characterization in patients with tumor-induced osteomalacia. J Bone Miner Res. Published 13 January 2024. doi:10.
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