Risk of Gallstone Disease in Primary Hyperparathyroidism: A Systematic Review and Meta-analysis
Pooled result · Pooled prevalence of GSDResult — go to the resultPooled odds ratio 1.77 95% CI 1.60–1.97Authors' conclusion
GSD is more prevalent in patients with PHPT than in the general population. Thus, PHPT may be considered an additional risk factor for GSD.
Study context
- Population
- Patients with primary hyperparathyroidism (PHPT) in observational studies reporting gallstone disease (GSD) prevalence; PubMed/MEDLINE, Embase, Web of Science searched from inception till May 10, 2023
- Participants
- 15,949 patients7 observational studies
- Comparison
- PHPT vs age- and sex-matched controls
- Outcome
- Pooled prevalence of GSD in PHPT and OR of GSD vs age- and sex-matched controls
Methodological detailsrandom-effects model with Hartung-Knapp adjustment, subgroup analysis by ethnicity (Indian/Caucasian)
- Random-effects model with Hartung-Knapp adjustment
- Subgroup analysis by ethnicity (Indian/Caucasian)
Pooled result
Pooled prevalence of GSD
Pooled odds ratio
1.77
95% CI 1.60–1.97
P < 0.001
By group
PHPT
16%
95% CI 7%–25%
PHPTvs Controls
pooled OR 1.77 (95% CI 1.60–1.97); P < 0.001
As reported in the abstract
Further pooled results
- Pooled prevalence of GSD in PHPT, Indians
- 13% · 95% CI 0%–66%
- Pooled prevalence of GSD in PHPT, Caucasians
- 17% · 95% CI 4%–31%
Original publication
Risk of Gallstone Disease in Primary Hyperparathyroidism: A Systematic Review and Meta-analysis. Endocr Pract. Published 10 December 2023. doi:10.
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