Prevalence of low bone mineral density (T-score ≤ − 2.5) in the whole spectrum of chronic kidney disease: a systematic review and meta-analysis
Authors' conclusion
The prevalence of LBMD in CKD patients is high, particularly in those undergoing dialysis and in cortical bone sites.
Study context
- Population
- Adults with chronic kidney disease (CKD) stages 3a-5D; Low bone mineral density (LBMD) defined by WHO criterion (T-score ≤ - 2.5); MEDLINE, EMBASE, Web of Science, CINAHL, LILACS searched from inception to February 2021
- Participants
- 78,092 adults153 studies
- Outcome
- Pooled prevalence of LBMD
Methodological detailsrandom-effect model, meta-regressions and subgroup analyses
- Random-effect model
- Meta-regressions and subgroup analyses
Pooled result
As reported in the abstract
Pooled global prevalence of LBMD in CKD
Pooled global prevalence of LBMD in CKD
24.5%
95% CI 21.3–27.8%
Further pooled results
Percent
Dialysis
30%(95% CI 25–35%)
Non-dialysis CKD
12%(95% CI 8–16%)
- Higher prevalence in dialysis vs non-dialysis CKD
- Subgroup analysis
Percent
Cortical sites
28%(95% CI 23–35%)
Trabecular sites
19%(95% CI 14–24%)
- Higher prevalence at cortical vs trabecular sites
- Subgroup analysis
Percent
European
26%(95% CI 21–30%)
Asiatic
25%(95% CI 21–29)
- Similar estimates in European and Asiatic continents
- Subgroup analysis
Original publication
Prevalence of low bone mineral density (T-score ≤ − 2.5) in the whole spectrum of chronic kidney disease: a systematic review and meta-analysis. Osteoporos Int. Published 12 November 2022. doi:10.
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