Pancreas Imaging of Children with Type 1 Diabetes Reveals New Patterns and Correlations with Pancreatic Functions
Authors' conclusion
Our study shows that longitudinal analysis of pancreases of children with T1D using multiparametric MRI improve the understanding of T1D heterogeneity both in the context of its onset and its evolution.
Study context
- Population
- Pediatric patients with new-onset T1D, followed during the first year postdiagnosismatched controls
- Participants
- 31 vs 29
- Exposure
- Children with new-onset T1D vs matched controls
- T1Dn = 31
- Controlsn = 29reference
- Outcome
- Pancreas volume (PV) at diagnosis (H1)
- Follow-up
- Diagnosis
Methodological detailsretrospective age-, BMI- and sex-matched controls, multiparametric magnetic resonance imaging (MRI)
- Retrospective age-, BMI- and sex-matched controls
- Multiparametric MRI
Main finding
As reported in the abstract
Significant decrease of pancreas volume (PV) in new-onset T1D vs controls
−45%
Increased pancreas atrophy in prepubertal patients
+25%
Observational data: associations, not effects.
Further findings
Association of MRI parameters with pancreatic function markers (H2)
- PV parameters correlated with C-peptide (PVTail) and trypsinogen (PVHead)
Prediction of pancreas functions by MRI parameters (H3) · first year postdiagnosis
- Biparametric regression models including MRI parameters predicted pancreas functions
Longitudinal evolution of PV parameters (H4) · 1 year postdiagnosis
- Correlation with PV at diagnosis
- R = −0.72
- Not correlated with markers of glucose homeostasis
Original publication
Pancreas Imaging of Children with Type 1 Diabetes Reveals New Patterns and Correlations with Pancreatic Functions. Pediatr Diabetes. Published 22 September 2023. doi:10.
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