Real-life data of hypoglycemic events in children and adolescents with type 1 diabetes
Authors' conclusion
This study shows that hypoglycemic events are a frequent phenomenon in children and adolescents with T1D, occurring regardless of overall metabolic control. Although patients with an HbA1c ≤48 mmol/mol had a higher frequency of mild hypoglycemic events there was no increase in serious hypoglycemic events.
Study context
- Population
- Children and adolescents with T1D with continuous glucose monitoring (CGM) data (mean 168±3 days)
- Participants
- 214 children
- Exposure
- Estimated HbA1c (eHbA1c) ≤48 vs 49-64 vs ≥65 mmol/mol
- ≤48 mmol/moln = 58
- 49-64 mmol/moln = 113
- ≥65 mmol/moln = 43
- Outcome
- Frequency of hypoglycemic events (<3.9 mmol/L) from CGM data
Methodological detailsCGM data analysed with computer-based algorithms
- CGM data analysed with computer-based algorithms
Main finding
As reported in the abstract
Hypoglycemic events per 24 hours (CGM)
- Hypoglycemic events (<3.9 mmol/L) identified from CGM
- 54 390
- Serious hypoglycemic events (<3.0 mmol/L)
- 11 740
- Self-reported severe hypoglycemia events
- 1
- Mean hypoglycemic events per 24 hours
- 1.5±0.1
- Mild (3.0-3.9 mmol/L) events per 24 hours
- 1.2±0.1
- Serious events per 24 hours
- 0.3±0.02
Observational data: associations, not effects.
Further findings
Correlation of eHbA1c with hypoglycemic events
- eHbA1c vs total daily hypoglycemic events, r (p<0.0001)
- −0.57
- eHbA1c vs mild hypoglycemic events, r (p<0.0001)
- −0.66
- eHbA1c vs serious hypoglycemic events, r (p=0.05, borderline)
- −0.13
Original publication
Real-life data of hypoglycemic events in children and adolescents with type 1 diabetes. BMJ Open Diabetes Res Care. Published 22 September 2023. doi:10.
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