Non‐invasive imaging of functional pancreatic islet beta‐cell mass in people with type 1 diabetes mellitus
Authors' conclusion
Manganese-enhanced magnetic resonance imaging provides a potential reproducible non-invasive measure of functional beta-cell mass in people with type 1 diabetes mellitus. This holds major promise for investigating type 1 diabetes, monitoring disease progression and assessing novel immunomodulatory interventions.
Study context
- Population
- People with T1D and healthy volunteers undergoing manganese-enhanced MRI of the pancreas after an oral glucose load
- Participants
- 15 / 10 / 10
- Comparison
- T1D with low or very low C-peptide vs healthy volunteers
- Healthy volunteersn = 15reference
- T1D low C-peptiden = 10
- T1D very low C-peptiden = 10
- Outcome
- Mean pancreatic manganese uptake
Main finding
As reported in the abstract
T1D low C-peptide vs Healthy volunteers: P ≤ 0.002 for both · T1D very low C-peptide vs Healthy volunteers: P ≤ 0.002 for both
Observational data: associations, not effects.
Further findings
Correlation of pancreatic manganese uptake with plasma C-peptide
- T1D: r
- 0.73, p < 0.001
- Healthy volunteers: r
- −0.054, p = 0.880
Correlation of manganese uptake with age, BMI or HbA1c
- No statistically significant correlations
Reproducibility of pancreatic manganese uptake (mL/100 g of tissue/min)
- Intra-observer mean difference (limits of agreement); ICC
- 0.31 (−1.42 to 2.05); ICC = 0.99
- Inter-observer mean difference (limits of agreement); ICC
- −1.23 (−5.74 to 3.27); ICC = 0.85
- Scan-rescan mean difference (limits of agreement); ICC
- −0.72 (−2.9 to 1.6); ICC = 0.96
- Scan-rescan in 10 participants
Original publication
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