In Vivo Imaging of the Innate Immune System in the Pancreas in New‐Onset and Long‐Standing Type 1 Diabetes
Authors' conclusion
PET imaging of innate immune cells in the pancreas is feasible. While no increased macrophage or neutrophil activity was observed in new-onset T1D, increased tracer uptake in long-standing T1D may reflect late-stage inflammatory processes and fibrosis.
Study context
- Population
- Individuals with new-onset or long-standing T1D and healthy controls
- Participants
- 4 / 6 / 6
- Comparison
- New-onset T1D and long-standing T1D vs healthy controls
- New-onset T1Dn = 4
- Long-standing T1Dn = 6
- Healthy controlsn = 6reference
- Outcome
- Feasibility of in vivo positron emission tomography (PET) imaging of pancreatic innate immune cell infiltration using [68Ga]-DOTATATE (M1 macrophages) and [11C]-NES (neutrophil elastase)
Main finding
As reported in the abstract
Pancreatic tracer uptake
- Both tracers enabled visualisation and quantification of pancreatic uptake
- Uptake of [68Ga]-DOTATATE and [11C]-NES not increased in new-onset T1D vs healthy controls
- Uptake of both tracers elevated in long-standing T1D
Original publication
In Vivo Imaging of the Innate Immune System in the Pancreas in New‐Onset and Long‐Standing Type 1 Diabetes. Diabetes Obes Metab. Published 23 March 2026. doi:10.
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