Paediatric Obesity Evaluation for Metabolic Susceptibility (POEMS)
Authors' conclusion
A child who has increased BMI (overweight/obese) and possesses risk factors for worsening glycemic status, if intervened with routine lifestyle modification advice, may still have increased risk of developing dysglycemia and type 2 DM. Therefore, understanding their risk profile provides opportunities to have a tiered and individualized approach.
Study context
- Population
- Children with increased body mass index (BMI) (overweight/obese) presenting to tertiary care at KK Women's and Children's Hospital, Singapore, for metabolic risk assessment, with more than one OGTT
- Participants
- 715 children
- Outcome
- Risk factors (OR) of worsening glycemic status from previously normal glucose tolerance, impaired fasting glucose or IGT, adjusted for intervention received
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Worsening glycemic status (to IGT or DM), ORs adjusted for intervention received
- Age >10 years, OR
- 4.94 (1.21 to 20.25) (CI)
- BMI rise, OR
- 1.71 (1.17 to 2.49) (CI)
- BMI increase >1.08 kg/m², OR
- 1.71 (1.16 to 2.51) (CI)
- Hyperlipidemia, OR
- 1.67 (1.12 to 2.50) (CI)
- Fatty liver disease, OR
- 2.11 (1.43 to 3.12) (CI)
Observational data: associations, not effects.
Further findings
Risk factors for developing impaired glucose tolerance (IGT)
- Born preterm, OR
- 3.49 (1.10 to 11.03)
- Hypertension, OR
- 1.61 (1.01 to 2.57)
- Hyperlipidemia, OR
- 1.80 (1.19 to 2.72)
- Fatty liver disease, OR
- 2.08 (1.39 to 3.13)
Dysglycemia at baseline by birth size
- SGA-IGT
- 8.8%
- SGA-DM
- 5.9%
- LGA-IGT
- 10.6%
- LGA-DM
- 11.8%
Original publication
Paediatric Obesity Evaluation for Metabolic Susceptibility (POEMS). BMJ Open Diabetes Res Care. Published 19 April 2023. doi:10.
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