Biomechanical CT to Assess Bone After Sleeve Gastrectomy in Adolescents With Obesity: A Prospective Longitudinal Study
Authors' conclusion
In conclusion, SG in adolescents decreased strength and volumetric BMD of the lumbar spine compared with nonsurgical controls. These changes were associated with decreases in visceral fat and muscle mass.
Study context
- Population
- Adolescents/young adults with obesity
- Participants
- 29 vs 30
- Exposure
- Sleeve gastrectomy (SG) vs nonsurgical controls
- SGn = 29
- Controlsn = 30reference
- Outcome
- Change in lumbar spine (L1–L2) strength and BMD by biomechanical quantitative computed tomography (QCT)
- Follow-up
- 12 months
Methodological detailsnonrandomized, 12-month
- Nonrandomized
- 12-month
Main finding
As reported in the abstract
Lumbar spine bone strength, bending stiffness, average and trabecular volumetric BMD
- SG vs Controls: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | SG | P value |
|---|---|---|
| Weight change · 12 monthsWeight unchanged in controls | average 34.3 ± 13.6 kg lost | P < 0.001 |
- Cortical bone mineral density (BMD), adjusted for change in body mass index (BMI) · 12 months · reduction in SG vs controls · controlled for change in BMI
- P = 0.02
- Abdominal adipose tissue and thigh muscle area · 12 months · significant reductions in SG vs controls
- P < 0.001
- Baseline BMI · higher in SG
- P = 0.01
Association of body composition with bone
- Reductions in strength and trabecular BMD associated with reductions in BMI, visceral adipose tissue and muscle
- P ≤ 0.03
Original publication
Biomechanical CT to Assess Bone After Sleeve Gastrectomy in Adolescents With Obesity: A Prospective Longitudinal Study. J Bone Miner Res. Published 19 April 2023. doi:10.
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