Changes in Hepatic Fat Content by CT 1 Year After Sleeve Gastrectomy in Adolescents and Young Adults With Obesity
Authors' conclusion
Hepatic fat content as assessed by noncontrast computed tomography improved after SG over 1 year in youth with obesity with resolution of NAFLD in all subjects. This was associated with decreases in visceral adiposity.
Study context
- Population
- Adolescents and young adults with obesity (mean age 18.2 ± .36 years)
- Participants
- 52 adolescents
- Exposure
- Sleeve gastrectomy (SG) vs nonsurgical controls
- SGn = 25
- NSn = 27reference
- Outcome
- Hepatic fat content by CT (liver/spleen ratio); abdominal fat by MRI
- Follow-up
- 12 months
Methodological details12-month prospective, nonsurgical controls
- 12-month prospective
- Nonsurgical controls
Main finding
As reported in the abstract
Liver-to-spleen (L/S) ratio, within-group change
| Group | Value | Within-group P |
|---|---|---|
| SG | .13 ± .05 | P = .014 |
SG
Value.13 ± .05
Within-group PP = .014
- SG vs NS: P = 0.055 — trend for a difference between groups
Observational data: associations, not effects.
Further findings
| Outcome | SG | NS | P value |
|---|---|---|---|
| Change in BMI · 12 monthsGreater decrease with SG | mean −12.5 ± .8 kg/m² | mean −.2 ± .5 kg/m² | P < 0.0001 |
Within SG: 12-month change in L/S ratio vs change in visceral fat
- Negative association (ρ)
- ρ = −.51 P = .016
Original publication
Changes in Hepatic Fat Content by CT 1 Year After Sleeve Gastrectomy in Adolescents and Young Adults With Obesity. J Clin Endocrinol Metab. Published 4 July 2023. doi:10.
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