Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity
An erratum to this article was published (Diabetes Obes Metab, Nov 2026 ↗)
Authors' conclusion
Moderate-severe OSA in children with obesity is associated with impaired insulin clearance and hepatic insulin sensitivity. These factors may contribute to hyperinsulinism in paediatric OSA.
Study context
- Population
- Children with obesity and suspected obstructive sleep apnea (OSA), assessed by nocturnal polygraphy and 3-hour OGTT
- Participants
- 70 children
- Exposure
- Moderate-severe OSA vs mild OSA
- Moderate-severe OSAn = 34
- Mild OSAn = 36reference
- Outcome
- Determinants of hyperinsulinemia: insulin clearance, secretion and sensitivity
Main finding
As reported in the abstract
Determinants of hyperinsulinemia
- Moderate-severe OSA vs Mild OSA: P = 0.008
- Moderate-severe OSA vs Mild OSA: P = 0.03
- Moderate-severe OSA vs Mild OSA: P = 0.07
- Moderate-severe OSA vs Mild OSA: P = 0.34
- Moderate-severe OSA vs Mild OSA: P = 0.53
- Moderate-severe OSA vs Mild OSA: P = 0.56
Observational data: associations, not effects.
Further findings
Correlations of OSA severity
- Fasting insulin clearance (negative correlation)
- r = −0.29, p = 0.01
- OGTT insulin clearance (negative correlation)
- r = −0.32, p = 0.007
- Hepatic insulin resistance index (HIRI) (positive correlation)
- r = 0.29, p = 0.02
Original publication
Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity. Diabetes Obes Metab. Published 14 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →