Effect of positive pressure ventilation and bariatric surgery on extracellular vesicle microRNAs in patients with severe obesity and obstructive sleep apnea
Authors' conclusion
Co-existance of OSA and severe obesity alters the profile of extracellular vesicle miRNAs. Bariatric surgery and weight loss did not reverse this effect meanwhile the treatment with CPAP in patients with severe obesity and OSA showed a recovery outcome in those extracellular vesicle miRNAs. Those facts remark the need for OSA screening in patients with severe obesity.
Study context
- Population
- Patients with severe obesity undergoing bariatric surgery, with and without obstructive sleep apnea (OSA) (EPIMOOSA study)completed the protocol
- Participants
- 15 vs 9
- Exposure
- OSA vs non-OSA in severe obesity; effect of continuous positive airway pressure (CPAP) and bariatric surgery
- OSAn = 15
- non-OSAn = 9reference
- Outcome
- Extracellular vesicle miRNA expression
Methodological detailssub-study of EPIMOOSA
- Sub-study of EPIMOOSA
Main finding
As reported in the abstract
- OSA after 6 months CPAP: significant decrease in miR21
- p < 0.01
- OSA after 6 months CPAP: significant decrease in miR126
- p < 0.001
- OSA after 6 months CPAP: significant decrease in miR320
- p < 0.001
Observational data: associations, not effects.
Original publication
Effect of positive pressure ventilation and bariatric surgery on extracellular vesicle microRNAs in patients with severe obesity and obstructive sleep apnea. Int J Obes (Lond). Published 25 October 2022. doi:10.
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