Lipids & metabolic liver disease
One‐hour post‐load glucose levels are associated with hepatic steatosis assessed by transient elastography
Main finding · Steatosis (CAP)Result — go to the resultOdds ratio 3.98 95% CI 1.43–11.13Authors' conclusion
Our data confirm that 1-hour PG ≥ 8.6 mmol/L is associated with higher signs of NAFLD, even among individuals with normal glucose tolerance, categorized as low risk by canonical diagnostic standards. TE is a safe low-impact approach that could be employed for stratifying the risk profile in these patients, with a high level of accuracy.
Study context
- Population
- Metabolically well-characterized non-diabetic White individuals undergoing transient elastography (TE)
- Participants
- 107 individuals
- Exposure
- 1-hour plasma glucose (PG) ≥ 8.6 mmol/L vs < 8.6 mmol/L
- Outcome
- Association of 1-hour PG with non-alcoholic fatty liver disease (NAFLD) markers by TE: CAP (steatosis) and liver stiffness (fibrosis)
Main finding
Steatosis (CAP)
Odds ratio
3.98
95% CI 1.43–11.13
P = 0.008
1-hour PG ≥ 8.6 mmol/Lvs 1-hour PG < 8.6 mmol/L
OR 3.98 (95% CI 1.43–11.13); P = 0.008
As reported in the abstract
- Controlled attenuation parameter (CAP) correlated with 1-hour PG (r), corrected for age, sex and body mass index (BMI)
- r = 0.301, P < 0.01
- 1-hour PG independent predictor of CAP in multivariable linear regression (β)
- β = 0.274, P = 0.008
Observational data: associations, not effects.
Further findings
Other correlates of CAP, corrected for age, sex and BMI
- Fasting insulin
- r = 0.285, P < 0.01
- 2-hour insulin
- r = 0.257, P < 0.02
- HOMA-IR
- r = 0.252, P < 0.01
- HDL-C
- r = −0.252, P < 0.02
- BMI
- r = 0.248, P < 0.02
- Age
- r = 0.212, P < 0.03
- Fasting insulin independent predictor of CAP (β)
- β = 0.225, P = 0.029
CAP after excluding subjects with prediabetes
- 1-hour PG sole predictor of CAP variation (β)
- β = 0.442, P < 0.001
Liver stiffness (LS)
- No association between 1-hour PG and LS
Original publication
One‐hour post‐load glucose levels are associated with hepatic steatosis assessed by transient elastography. Diabetes Obes Metab. Published 12 November 2023. doi:10.
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