Lipids & metabolic liver disease
Serum Tsukushi Level Is Associated With the Severity of Liver Fibrosis Independent of Type 2 Diabetes
Authors' conclusion
Serum TSK levels were increased in subjects with NAFLD and reflected the severity of liver fibrosis.
Study context
- Population
- Individuals with and without T2D undergoing transient elastography; Nonalcoholic fatty liver disease (NAFLD) defined as controlled attenuation parameter ≥ 248 dB/m
- Participants
- 393 vs 289
- Exposure
- NAFLD vs no NAFLD, in subjects with and without T2D
- Diabetes mellitus (DM)n = 393
- Without DMn = 289reference
- Outcome
- Association between serum TSK (ELISA) and severity of NAFLD (liver steatosis and fibrosis)
Main finding
As reported in the abstract
Serum TSK in NAFLD vs no NAFLD
NAFLD present in DM
276
70.2%
NAFLD present without DM
129
44.6%
Observational data: associations, not effects.
Further findings
| Outcome | Serum TSK | Fibrosis-4 index | P value |
|---|---|---|---|
| AUC for advanced fibrosis or cirrhosis among NAFLD (49 of 405)Significantly better with serum TSK | P < 0.05 | ||
| AUC | 0.70 (95% CI .62-.77) | 0.64 (95% CI .55-.72) |
Original publication
Serum Tsukushi Level Is Associated With the Severity of Liver Fibrosis Independent of Type 2 Diabetes. J Clin Endocrinol Metab. Published 2 November 2023. doi:10.
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