Obesity‐related early structural alterations in the retina detected by optical coherence tomography
Authors' conclusion
Retinal SD-OCT imaging detected structural alterations in distinct retinal layers between healthy, asymptomatic individuals in non-obese and pre-obese/obese groups. Besides a decreased volume of the retinal nerve fibre layer, a significant increase was detected in the inner nuclear layer volume with a high BMI, possibly due to Müller glia responses to obesity-related osmotic, metabolic and inflammatory stress, awaiting further investigation.
Study context
- Population
- Healthy asymptomatic participants; retinal spectral-domain optical coherence tomography (SD-OCT) scans
- Participants
- 92 eyes
- Exposure
- Pre-obese/obese vs non-obese
- Outcome
- Retinal layer volumes on SD-OCT
Main finding
As reported in the abstract
- Pre-obese/obese vs Non-obese: P = 0.048
- Pre-obese/obese vs Non-obese: P = 0.036
Observational data: associations, not effects.
Further findings
Regional retinal nerve fibre layer volume difference
- Superior parafoveal
- P = 0.033
- Inferior parafoveal
- P = 0.001
- Nasal perifoveal
- P = 0.041
Regional inner nuclear layer changes
- Inferior perifoveal
- P = 0.009
Stepwise hierarchical binary logistic regression, adjusted for age and gender
- Regionally decreased retinal nerve fibre layer volume and increased inner nuclear layer volume significantly associated with high body mass index (BMI)
- P = 0.001
Original publication
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