Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery
Authors' conclusion
These findings provide a mechanistic understanding of how bariatric surgery leads to systemic changes in metabolic and haemostatic pathways, thus favourably modulating the risk of developing cardiovascular disease.
Study context
- Population
- Obese patients undergoing RYGB
- Comparison
- Plasma proteome 9 months after RYGB vs before surgery
- Outcome
- Differentially abundant plasma proteins
- Follow-up
- 9 months after surgery
Methodological detailsbefore-after (pre- and 9 months post-surgery), quantitative proteomics (SWATH-MS), gene set enrichment analysis
- Before-after (pre- and 9 months post-surgery)
- Quantitative proteomics (SWATH-MS)
- Gene set enrichment analysis
Main finding
As reported in the abstract
Proteins increased in abundance
27
Proteins decreased in abundance
43
Original publication
Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery. Diabetes Obes Metab. Published 25 February 2025. doi:10.
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