Alterations in Thyroid Hormones in Obese Patients Are Associated With Body Composition Changes After Bariatric Surgery
Authors' conclusion
MBS significantly affects thyroid function and TH resistance, with notable correlations to changes in body composition.
Study context
- Population
- Obese euthyroid individuals and controls; obese patients undergoing metabolic/bariatric surgery (MBS)
- Participants
- 470 / 118 / 125
- Exposure
- Obese individuals vs controls at baseline; before vs after MBS
- Obesen = 470
- Controlsn = 118reference
- MBSn = 125
- Outcome
- Correlations of thyroid function with body composition
Main finding
As reported in the abstract
- Preoperative TSH vs visceral fat area (VFA) (partial correlation, adjusted for age and sex)
- r = 0.109; P = .019
- Preoperative TSH vs body fat percentage
- r = 0.114; P = .013
- Preoperative TSH vs skeletal muscle mass (SMM) percentage
- r = −0.104; P = .024
- Post MBS: decreased TSH vs decreased VFA
- r = 0.251; P = .006
- Post MBS: decreased TSH vs increased SMM percentage
- r = 0.233; P = .011
Observational data: associations, not effects.
Further findings
Thyroid function and body composition after MBS
- In obese, TSH, free triiodothyronine (fT3) and TFQI elevated and significantly decreased post MBS, with VFA and body fat percentages; SMM percentage increased
Original publication
Alterations in Thyroid Hormones in Obese Patients Are Associated With Body Composition Changes After Bariatric Surgery. J Clin Endocrinol Metab. Published 2 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →