The effectiveness and sustainability of health outcomes from a holistic digital weight‐loss service with concomitant initiation of tirzepatide: A pragmatic randomized controlled trial in the UK
Authors' conclusion
This RCT will be the first to assess the effectiveness and sustainability of a real-world intensive, multidisciplinary DWLS, and it should highlight the potential of such a service for long-term obesity treatment compared with programmes that deliver standard health counselling.
Study context
- Population
- Non-diabetic patients of the Juniper UK digital weight-loss service; mean age 44.6 (± 11.4) years, mean BMI 34.8 (± 7.5) kg/m², 81.0% womenenrolled
- Participants
- 688 patients
- Comparison
- Personalized weekly lifestyle coaching plus tirzepatide vs group counselling session plus tirzepatide
- Primary endpoint
- Co-primary: weight loss, fat-free to fat-mass ratio and composite strength vs baseline
- Follow-up
- 12 months (6 months after end of treatment)
Methodological detailsprotocol with baseline characteristics, observer-blinded, pragmatic
- Protocol with baseline characteristics
- Observer-blinded
- Pragmatic
Primary result
As reported in the abstract
Baseline characteristics
- Mean age
- 44.6 (± 11.4) years
- Mean BMI
- 34.8 (± 7.5) kg/m²
- Women
- 81.0%
- White ethnicity
- 72.8%
- Dyslipidaemia
- 42.4%
- Hypertension
- 35.3%
- High cholesterol
- 31.8%
Original publication
The effectiveness and sustainability of health outcomes from a holistic digital weight‐loss service with concomitant initiation of tirzepatide: A pragmatic randomized controlled trial in the UK. Diabetes Obes Metab. Published 2 September 2024. doi:10.
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