Digital engagement enhances dual GIP / GLP ‐1 receptor agonist and GLP ‐1 receptor agonist efficacy: A retrospective cohort analysis of a digital weight loss service on outcomes and safety

Johnson, H; Clift, AK; Reisel, D; Huang, DR

doi:10.1111/dom.70244

Obesity

Digital engagement enhances dual GIP / GLP ‐1 receptor agonist and GLP ‐1 receptor agonist efficacy: A retrospective cohort analysis of a digital weight loss service on outcomes and safety

Diabetes Obes MetabPublished 27 Oct 2025Retrospective cohort study

Main finding · Adjusted weight lossResultAbsolute difference 4.5 percentage points

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Authors' conclusion

Digital engagement was associated with 4.5 percentage points greater weight loss (21.5% vs. 17.0%), faster milestone achievement, and comparable safety profiles.

Study context

Population: Adults prescribed dual GIP/GLP-1 RA or GLP-1 RA, Voy digital weight loss service, United Kingdom (UK), August 2024–July 2025; mean age 42.3 ± 12.7 years, 77.9% female, baseline BMI 35.2 ± 6.2 kg/m²
Participants: 106,653 adults

Exposure: Digitally engaged vs not engaged patients on dual GIP/GLP-1 RA or GLP-1 RA
Engagedn = 6,086
Not engagedn = 100,567reference
Outcome: Adjusted weight loss
Follow-up: 11 months

Methodological detailslongitudinal, national digital weight loss service

Longitudinal
National digital weight loss service

Main finding

As reported in the abstract

Absolute difference

4.5 percentage points

P < 0.001

By group

Engaged21.5%95% CI −22.0–-21.1

Not engaged17.0%CI −17.2–-16.8

Observational data: associations, not effects.

Further findings

Outcome	← Lower with engaged ←→ Higher with engaged →	Estimate	P value
Attainment of weight loss milestonesEngagedvs Not engaged	0.512	HR (≥5%) 1.42 (95% CI 1.38–1.46)	all p < 0.001
Attainment of weight loss milestonesEngagedvs Not engaged	0.512	HR (≥10%) 1.46 (95% CI 1.41–1.52)	all p < 0.001
Attainment of weight loss milestonesEngagedvs Not engaged	0.512	HR (≥15%) 1.53 (95% CI 1.45–1.61)	all p < 0.001
Attainment of weight loss milestonesEngagedvs Not engaged	0.512	HR (≥20%) 1.62 (95% CI 1.50–1.75)	all p < 0.001
Attainment of weight loss milestonesEngagedvs Not engaged	0.512	HR (≥25%) 1.86 (95% CI 1.64–2.10)	all p < 0.001
	0.512Ratio (log scale)

Safety

Outcome	← Lower risk with engaged ←→ Higher risk with engaged →	IRR (95% CI)
Safety events · over 290 050 patient-monthsNo excess risk in engaged groups	0.512	0.83 (0.60–1.15)
	0.512Incidence rate ratio (log scale)

Safety events — Overall incidence: 1.57 per 1000 patient-months

Original publication

Digital engagement enhances dual GIP / GLP ‐1 receptor agonist and GLP ‐1 receptor agonist efficacy: A retrospective cohort analysis of a digital weight loss service on outcomes and safety. Diabetes Obes Metab. Published 27 October 2025. doi:10.1111/dom.70244

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