The prognostic role of cardiopulmonary exercise testing in obesity
Main finding · All-cause mortalityResult — go to the resultRisk of mortality (adjusted Cox regression) 20-fold higherAuthors' conclusion
Given the strong association of VO2, ventilatory efficiency, circulatory and ventilatory power with all-cause mortality, our findings support the notion that poorer cardiorespiratory fitness is associated with a poor prognosis in patients with obesity.
Study context
- Population
- Obese patients of both sexes (mean age 40 ± 13 years) who underwent cardiopulmonary exercise testing (CPET) for clinical reasons, 1 March 2009–1 December 2023; 70% women
- Participants
- 469 patients
- Exposure
- pVO2 ≤16 vs >16 mL/kg/min
- Outcome
- All-cause mortality
- Follow-up
- Mean 69 ± 48 months
Main finding
As reported in the abstract
Risk of mortality (adjusted Cox regression)
20-fold higher
- Deaths
- 46
- Annual mortality rate
- 2%
- Lower pVO2, circulatory power and ventilatory power values associated with survival (Kaplan-Meier, log-rank)
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Deaths by sexMen vs Women · more deaths in men (18 vs. 6%) | P < 0.001 |
Optimal ROC thresholds for discrimination of survival
- pVO2
- ≤16 mL/kg/min
- VE/VCO2 slope
- ≥31
- Ventilatory power
- ≤5.8 mmHg
- Circulatory power
- ≤2980 mmHg/mL O2/min
Original publication
The prognostic role of cardiopulmonary exercise testing in obesity. Diabetes Obes Metab. Published 30 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →