Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity
Authors' conclusion
While BW without obesity had lower Rd than WW, race and obesity did not synergistically impact peripheral IR. Paradoxically, WW with obesity had greater hepatic IR compared to BW. Relationships between SM respiration and IR persisted across a range of body weights. These data provide support for therapies in BW, like exercise, that improve SM mitochondrial respiration to reduce IR and T2D risk.
Study context
- Population
- Non-Hispanic Black and White women with and without obesity
- Participants
- 32 vs 32
- Exposure
- Black vs White women, with and without obesity
- Black women (BW)n = 32
- White women (WW)n = 32reference
- Outcome
- Hepatic and peripheral IR measured by labeled hyperinsulinemic-euglycemic clamp
Methodological detailshyperinsulinemic-euglycemic clamp, mixed model ANOVA
- Hyperinsulinemic-euglycemic clamp
- Mixed model ANOVA
Main finding
As reported in the abstract
- Subjects with obesity had greater hepatic and peripheral insulin resistance (IR) and lower skeletal muscle (SM) respiration (P < .001)
- BW had 14% greater insulin (P = .066)
- Maximal coupled and uncoupled SM mitochondrial respiration strongly correlated with peripheral and hepatic IR (P < .01)
- BW vs WW: P = 0.062
- BW vs WW: P = 0.002
- BW vs WW: P = 0.005
- BW vs WW: P = 0.024
- BW vs WW: P < 0.001
Observational data: associations, not effects.
Original publication
Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity. J Clin Endocrinol Metab. Published 29 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →