Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity
Authors' conclusion
In this population of adults with overweight or obesity, use of tirzepatide was associated with significantly greater weight loss than semaglutide. Future study is needed to understand differences in other important outcomes.
Study context
- Population
- Adults with overweight or obesity, regular care in prior year, no prior GLP-1 RA use, available baseline weight; initiated May 2022–September 2023; mean age 52.0 years, 70.5% female, 52.0% T2D, mean baseline weight 110 kg18,386 after matching
- Participants
- 41,222 adults
- Exposure
- Tirzepatide vs semaglutide
- Tirzepatiden = 9,193
- Semaglutiden = 32,029reference
- Outcome
- On-treatment weight change in propensity score-matched population: hazard of achieving ≥5%, ≥10% and ≥15% weight loss, and % change in weight
- Follow-up
- 3, 6, and 12 months
Methodological detailspropensity score-matched, electronic health record (EHR) data linked to dispensing information, US health care systems
- Propensity score-matched
- EHR data linked to dispensing information
- US health care systems
Main finding
As reported in the abstract
Achieving weight loss
Tirzepatide vs SemaglutideHazard ratio (95% CI)
≥5% weight loss
1.76(1.68–1.84)
≥10% weight loss
2.54(2.37–2.73)
≥15% weight loss
3.24(2.91–3.61)
Tirzepatide vs SemaglutideDifference, % (95% CI)
% weight change at 3 months; larger with tirzepatide
−2.4(−2.5% to −2.2%)
% weight change at 6 months; larger with tirzepatide
−4.3(−4.7% to −4.0%)
% weight change at 12 months; larger with tirzepatide
−6.9(−7.9% to −5.8%)
Observational data: associations, not effects.
Further findings
Follow-up ended by discontinuation
Safety
- Rates of gastrointestinal adverse events (AEs) were similar between groups
Original publication
Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. Published 1 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →