Effectiveness and adherence in a tirzepatide‐supported digital weight‐loss programme in Australia: A real‐world observational study
Authors' conclusion
Tirzepatide plus multidisciplinary digital care yields large clinically meaningful weight loss among engaged users, but low adherence limits population-level effectiveness. Early clinical response and sustained engagement are key drivers of adherence; however, interventions are needed to manage early weight-loss expectations.
Study context
- Population
- Australian patients initiating tirzepatide through the Juniper AU DWLS, 1 September 2024–23 April 2025; 92.9% female, 81.9% Caucasian, mean age 41.46 years, mean baseline BMI 32.9 kg/m²
- Participants
- 4,309 patients
- Outcome
- Programme adherence and mean percentage weight loss among adherent patients
- Follow-up
- 6 and 12 months
Methodological detailsreal-world, last observation carried forward imputation
- Real-world
- Last observation carried forward imputation
Main finding
As reported in the abstract
- Met adherence criteria at 6 months
- 31.7%
- Mean weight loss among adherent patients at 6 months
- 16.9% (±8.6; 95% CI 16.6-17.2)
- ≥5% weight reduction at 6 months
- 98.0%
- Adherent at 12 months
- 16.1%
- Mean weight loss at 12 months
- 22.7% (±7.2; 95% CI: 19.8-22.6)
- ≥5% weight reduction at 12 months
- 100%
Observational data: associations, not effects.
Further findings
- 1-month weight loss was the strongest predictor of 6- and 12-month outcomes (multivariable models)
- Sustained weekly weight tracking and health coach messaging strongly associated with retention and greater weight loss
- Very frequent weight tracking in month one correlated with poorer outcomes and reduced retention
Safety
- Side effects common but mostly mild/moderate; did not correlate with weight loss or programme retention
Original publication
Effectiveness and adherence in a tirzepatide‐supported digital weight‐loss programme in Australia: A real‐world observational study. Diabetes Obes Metab. Published 14 January 2026. doi:10.
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