Novel Protocol for the Use of Advanced Hybrid Closed-Loop System in Adolescents Engaged in Contact Sports
Main finding · Time in target range (70-180 mg/dL)Result — go to the resultMean difference +0.79 %Authors' conclusion
The predefined regimen, including a temporary target before and disconnection of AHCL during football training, was safe and may provide satisfactory glucose control in active adolescents with T1D. This protocol could be adapted for use in other intensive contact sports.
Study context
- Population
- Adolescent boys with T1D playing junior league football, aged 14.9 years (25–75th percentile: 14–15.5), diabetes duration 5.7 years (5.2–7), on AHCL (MiniMed780G)
- Participants
- 11 participants
- Exposure
- AHCL protocol during sports camp vs preceding week
- Outcome
- Time in target range (70-180 mg/dL)
Methodological detailssingle-arm, pre-post comparison
- Single-arm
- Pre-post comparison
Main finding
As reported in the abstract
Mean difference
+0.79 %
P = 0.7581
By group
Preceding week
79.34
mean · ± 8.46 · %
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Median glucoseLower with Camp (dropped); ± 12.08 mg/dL | difference 10.91 mg/dL | P = 0.0134 |
| Time in tight target rangeHigher with Camp (increased); ± 11.60% | difference 11.41 % | P = 0.0008 |
| Relative amount of automated bolus insulinLower with Camp (decreased); ± 4.65% | difference 14.24 % | P < 0.0001 |
- Moderate-to-vigorous physical activity during camp
- 6.6 · range 6–6.9 · h/day
Relative amount of automated bolus insulin
- Daily insulin dose and basal/bolus ratio remained comparable with baseline
Safety
- Tight-range gain without increasing time below range (<70 mg/dL) or glycemic variability
Original publication
Novel Protocol for the Use of Advanced Hybrid Closed-Loop System in Adolescents Engaged in Contact Sports. Horm Res Paediatr. Published 25 October 2024. doi:10.
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