The Feasibility of an Experimental Hypobaric Simulation to Evaluate the Safety of Closed-Loop Insulin Delivery Systems in Flight-Related Atmospheric Pressure Changes
Authors' conclusion
While not demonstrating any apparent issues, repeating flight simulation protocol with other systems, examining longer flights, and undertaking larger, powered randomised controlled trials can confirm their safety in aviation.
Study context
- Population
- People with T1D on hybrid closed-loop (HCL) systems, fasting and post-prandial states750 glucose measurements
- Participants
- 4 / 1 / 1
- Comparison
- Simulated flight cabin pressures of 550 mmHg and 750 mmHg
- Medtronic Guardian 4-Medtronic 780G-SmartGuardn = 4
- Dexcom G6-Omnipod DASH-Android APSn = 1
- Dexcom G6-Ypsomed Pump-CamAPSn = 1
- Outcome
- Feasibility of HCL safety evaluation using hypobaric chamber flight simulation
Methodological detailspreliminary, hypobaric chamber flight simulation
- Preliminary
- Hypobaric chamber flight simulation
Main finding
As reported in the abstract
Glucose measurements taken
750
Glucose showed a stable decline during fasting, to
4 mmol/L
Original publication
The Feasibility of an Experimental Hypobaric Simulation to Evaluate the Safety of Closed-Loop Insulin Delivery Systems in Flight-Related Atmospheric Pressure Changes. Diabetes Technol Ther. Published 24 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →