Novel OGTT metrics do not provide incremental predictive value beyond conventional glycemic criteria for remission of prediabetes in individuals with impaired fasting glucose: results from the PREVIEW trial
Authors' conclusion
In long-term lifestyle intervention among individuals who predominantly had IFG, individual novel OGTT metrics do not provide incremental predictive value for prediabetes remission beyond conventional metrics of glycemia.
Study context
- Population
- Adults with overweight/obesity and predominantly impaired fasting glucose (IFG) in a lifestyle intervention trial (8-week weight loss, then 148-week weight maintenance)
- Participants
- 1,187 adults
- Comparison
- Novel OGTT metrics vs conventional glycaemic metrics for predicting prediabetes remission
- Remittersn = 262
- Non-remittersn = 925reference
- Primary endpoint
- Prediabetes remission
- Follow-up
- 1, 2, and 3 years
Methodological detailspost-hoc analysis, multinational, 3-year
- Post-hoc analysis
- Multinational
- 3-year
Primary result
As reported in the abstract
Incremental predictive value of novel OGTT metrics for prediabetes remission beyond conventional metrics
- Adding individual novel OGTT metrics did not significantly improve model fit or discrimination (likelihood ratio tests, ΔAUROC, net reclassification improvement (NRI))
- P > 0.05
Further findings
Baseline fasting glucose and prediabetes remission · 1 year
- Non-linear association at 1 year
- P = 0.008
- Inverse linear associations at 2 and 3 years, independent of 2-h glucose and HbA1c
Baseline HbA1c and 2-h glucose and prediabetes remission · 1, 2, and 3 years
- Higher baseline HbA1c, but not 2-h glucose, associated with lower likelihood of remission, regardless of fasting and 2-h glucose
Original publication
Novel OGTT metrics do not provide incremental predictive value beyond conventional glycemic criteria for remission of prediabetes in individuals with impaired fasting glucose: results from the PREVIEW trial. Cardiovasc Diabetol. Published 22 April 2026. doi:10.
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