Long-term effects of dietary protein and carbohydrate quality on prediabetes remission: results from the PREVIEW randomised multinational diabetes prevention trial
Primary result · Prediabetes remission (return to normal fasting glucose and normal glucose tolerance)Result — go to the resultRR for prediabetes remission 1.26 95% CI 1.04–1.53Authors' conclusion
Following rapid weight loss, a prudent diet with moderate protein and moderate GI was more effective for long-term prediabetes remission than a high-protein, low-GI diet, irrespective of weight change.
Study context
- Population
- Adults with overweight/obesity and prediabetes (fasting glucose 5.6–6.9 mmol/l and/or 2 h glucose 7.8–11.0 mmol/l on OGTT), after an 8-week low-energy diet rapid weight loss programme, followed by 3 year weight maintenance lifestyle interventionmodified ITT
- Participants
- 1,856 adults
- Comparison
- Moderate-protein, moderate-GI prudent diet vs high-protein, low-GI diet
- Moderate-protein, moderate-GIn = 923
- High-protein, low-GIn = 933reference
- Primary endpoint
- Prediabetes remission (return to normal fasting glucose and normal glucose tolerance)
- Follow-up
- 1 year or 3 years
Methodological details3 year, multicentre, parallel, multinational
- 3 year
- Multicentre
- Parallel
- Multinational
Primary result
As reported in the abstract
1 year
RR for prediabetes remission
1.26
95% CI 1.04–1.53
P = 0.025
By group
Moderate-protein, moderate-GIvs High-protein, low-GI
RR for prediabetes remission 1.26 (95% CI 1.04–1.53); P = 0.025
Secondary outcomes
| Outcome | Moderate-protein, moderate-GI | High-protein, low-GI | RR for prediabetes remission (95% CI) | P value | |
|---|---|---|---|---|---|
| Prediabetes remission (return to normal fasting glucose and normal glucose tolerance) · 3 yearsHigher remission with moderate-protein, moderate-GI · modified intention-to-treat · adjusted for age and sex | 20.6% | 15.5% | 1.26 (1.06–1.50) | P = 0.015 | |
| 0.512RR for prediabetes remission (log scale) |
Met weight loss maintenance target (≥8% of initial body weight) · 1 year
P = 0.215
Met weight loss maintenance target (≥8% of initial body weight) · 3 years
P = 0.793
Body weight and composition changes · 3 years
- Body weight and composition changes were similar between diets; remission differences were independent of body weight and composition changes
Original publication
Long-term effects of dietary protein and carbohydrate quality on prediabetes remission: results from the PREVIEW randomised multinational diabetes prevention trial. Diabetologia. Published 15 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →