MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial
Primary result · AUC of glucose during 2 h OGTT after high-carbohydrate/high-GI dietResult — go to the resultβ 134.32 mmol/l × minAuthors' conclusion
Our study shows that carrying the risk G allele of MTNR1B-rs10830963 is associated with greater glycaemic responses after consuming a diet with high carbohydrates and high GI levels. Reducing GI in a high-carbohydrate diet may decrease post-OGTT glucose concentrations among the risk G-allele carriers.
Study context
- Population
- Participants of a randomised crossover controlled feeding trial of four diets with high/low glycaemic index (GI) and high/low carbohydrate content, genotyped for MTNR1B-rs10,830,963crossover
- Participants
- 150 participants
- Comparison
- MTNR1B-rs10830963 risk G-allele carriers (CG/GG) vs CC genotype; effects of carbohydrate quantity and GI on OGTT glucose response
- Primary endpoint
- Glucose response (AUC and increments) during 2 h OGTT by MTNR1B-rs10830963 genotype
- Follow-up
- End of each 5-week diet intervention
Methodological detailsfour diets (high/low GI, high/low carbohydrate), 5 weeks per diet
- Four diets (high/low GI, high/low carbohydrate)
- 5 weeks per diet
Primary result
As reported in the abstract
AUC of glucose during 2 h OGTT after high-carbohydrate/high-GI diet
β
134.32 mmol/l × min
P = 0.004
Further findings
| Outcome | β (mmol/l) | P value |
|---|---|---|
| Glucose increment 0-60 min after high-carbohydrate/high-GI dietSE 0.47; not seen after the other three diets | 1.26 | P = 0.008 |
| Glucose increment 0-90 min after high-carbohydrate/high-GI dietSE 0.50; not seen after the other three diets | 1.10 | P = 0.028 |
Reducing GI at high carbohydrate content: 60 min post-OGTT glucose
- Mean change, mmol/l (95% CI −1.18, −0.17); particularly in risk G-allele carriers (pinteraction <0.05)
- −0.67
Reducing GI at high carbohydrate content: glucose increment 0-60 min
- Mean change, mmol/l (95% CI −1.67, −0.33); particularly in risk G-allele carriers (pinteraction <0.05)
- −1.00
- Increment 0-90 min also decreased, particularly in risk G-allele carriers
Original publication
MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial. Diabetologia. Published 5 December 2023. doi:10.
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