The effect of Mankai plant consumption on postprandial glycaemic response among patients with type 2 diabetes: A randomized crossover trial
Authors' conclusion
Mankai consumption may mitigate the PG response in people with T2D with an ~20% improvement in glycaemic values. These findings provide case-study evidence for plant-based treatments in T2D to complement a healthy lifestyle and pharmacotherapy.
Study context
- Population
- Adults with T2D (HbA1c 6.5%-8.5%) from two sites in Israel, without dietary, physical activity or pharmacotherapy changes; Continuous glucose monitoring (CGM)-monitored40 completed
- Participants
- 45 adults
- Comparison
- Postdinner Mankai drink vs water
- Primary endpoint
- Postprandial glucose (PG) excursions by CGM
Methodological detailscrossover-controlled, two sites, 4-day washout, Adherence rate 88.5%; 743 person-intervention-days
- Crossover-controlled
- Two sites
- 4-day washout
- Adherence rate 88.5%; 743 person-intervention-days
Primary result
As reported in the abstract
PG peak (∆peak)
P < 0.001
Further findings
Time-to-peak · time-to-peak delayed by 20.0% with Mankai
P < 0.001
PG incline slope
P < 0.001
| Outcome | Mankai | Water | P value |
|---|---|---|---|
| PG decline slope | −6.1 mg/[dL h] | −7.9 mg/[dL h] | P < 0.01 |
| Change in TG/HDL-C ratio · 2 weeks | −0.5 ± 1.3 | +0.3 ± 1.5 | P = 0.05 |
- Mean postprandial net incremental AUC of glucose · lowered by 20.1% with Mankai
- P = 0.03
Sensitivity and subgroup analyses
- Results consistent across several sensitivity and subgroup analyses, including across antidiabetic pharmacotherapy groups
Original publication
The effect of Mankai plant consumption on postprandial glycaemic response among patients with type 2 diabetes: A randomized crossover trial. Diabetes Obes Metab. Published 12 August 2024. doi:10.
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